Urine Diagnostic Drug of Abuse Test Kit EDDP ( METHADONE METABOLITE
EDDP is the primary metabolite of methadone. Methadone is a
controlled substance and is used for detoxification and maintenance
of opiate-dependent patients. Patients on methadone maintenance may
exhibit methadone (parent) levels that account for 5-50% of the
dosage and 3-25% of EDDP in urinary excretion during the first 24
hours. The tampering of specimens by spiking the urine with
methadone can be prevented. Also, renal clearance of EDDP is not
affected by urinary pH; therefore the EDDP test provides a more
accurate result of methadone ingestion than the methadone test.
Methadone is an unusual drug in a sense that its primary urinary
metabolites (EDDP and EMDP) are cyclic in structure. Thus,
theyarevery difficult to detect with immunoassays targeted to the
native compound. Exacerbating this problem, there is a subsection
of the population classified as “extensive metabolizers” of
methadone. In these individuals, a urine specimen may not contain
enough parent methadone to yield a positive drug screen even if the
individual is in compliance with their methadone maintenance.
|Test||Drug-free||Low Negative (Less than half the cutoff concentration)||Near Cutoff Negative (Between 50% below the cutoff and the cutoff
concentration)||Near Cutoff Positive (Between the cutoff and 50% above the cutoff
concentration)||High Positive (greater than 50% above the cutoff concentration)|
Note: this test will be negative when taking "natural" opiates, such as
heroine, codeine or opium. Thus, this test is usable to verify that
a patient is undergoing his treatment.
This test replaces the MTD tests used so far because it is more
reliable and helps to prevent number of attempts to cheat. With a
conventional MTD test, the result will be positive even if the
patient puts few drops of methadone in his urine sample before the
test. With the EDDP test, these manipulations are now doomed to
failure, because it is not a simple methadone test, but a consumed methadone test (since it detects the metabolite).
NEGATIVE:* Two lines appear. One red line should be in the control region
(C), and another apparent red or pink line should be in the test
region (T). This negative result indicates that the Phencyclidine
concentration is below the detectable level (25 ng/mL). *NOTE: The shade of red in the test line region (T) will vary, but it
should be considered negative whenever there is even a faint pink
POSITIVE: One red line appears in the control region (C). No line appears
in the test region (T). This positive result indicates that the
Phencyclidine concentration exceeds the detectable level (25
INVALID: Control line fails to appear. Insufficient specimen volume or
incorrect procedural techniques are the most likely reasons for
control line failure. Review the procedure and repeat the test with
a new test strip. If the problem persists, discontinue using the
test kit immediately and contact your local distributor.
Condition for use
- Drug testing in your own home.
- Random testing employees in the workplace.
- Reasonable suspicion drug testing.
- Random drug testing in schools or youth organizations.
- Drug testing in health care facilities, pain centers, and other